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Multiple sclerosis oligo or multiple sclerosis (English: disseminated sclerosis, oligo disseminated encephalomyelitis, multiple sclerosis, MS) is an inflammatory disorder that occurs oligo in the brain and spinal cord caused by many factors, especially the focal lymphocytic infiltration (T cells continuously migrate to the location and proper conduct such attacks occur in any infection) and resulted in the destruction of myelin and axons.
At first, any inflammation that occurs oligo gradually became mitigated so as to allow regeneration of myelin membrane. At this time, the early symptoms of MS is still in the form of episodes of neurological dysfunction repeatedly improved.
However, with berselangnya time, cytokines secreted by T cells activates a number of microglia, and astrocytes kind of phagocytes who settled in brain tissue and spinal cord, and brain barrier dysfunction and chronic neurodegenerative sustainable.
In paraklinis, discovered the respiratory chain complex I deficiency in the mitochondria, and axonal damage and bruising on the brain and spinal cord as a result of acute phase inflammation and gliosis that occur repeatedly in the axons and glia. The ratio of IL-12 and IFN-gamma in the blood also increased. oligo Pathophysiology Multiple Stages of development skeloris oligo begins with latent damage to the blood-brain barrier, whenever there is extravasation of CD8 + T cells and CD4 T cells induced by CCL2 kemokina. Damage to blood-brain barrier can also disebakan by granulocyte migration. Giving an antibody that inhibits the expression of CXCR2 perceiving oligo ELR + - perceiving CXCR2 binding kemokina CXCL1, CXCL2 and CXCL5 in the brain - which increased in line with the migration of granulocytes, oligo in a mouse model, proven oligo to reduce infiltration of granulocytes at the same memory T cells by> 95%, and stop damage to the blood-brain barrier. In viral infections, it caused 100% mortality. Blood-brain oligo barrier dysfunction can be prevented by administration of natalizumab, a substance that inhibits alpha (4) -integrin, organic compounds needed to perform the adhesion of monocytes to the vascular cell adhesion molecule oligo type 1 (VCAM-1) and the CS1 region containing fibronectin (FN-CS1 ), the extravasation in the brain barrier oligo to be able to migrate into the central nervous system. Types of Relapsing-remitting MS Primary Secondary oligo progressive, progressive relapsing Progressive oligo Epidemiology
In northern oligo Europe, North America, and Australasia, about 1000 citizens suffering from multiple sclerosis, while in Arabia, Asia, and South America, the percentage is much lower. In sub-Saharan Africa, MS is very rare. With a few exceptions, there is a north-south gradient in the northern hemisphere and the south-north gradient in the southern hemisphere, oligo with MS more rare around the equator. oligo
Some people with MS are famous Stan Belinda Michael Blake Clive Burr Neil Cavuto Betty Cuthbert oligo Joan Didion Jacqueline du Pre Stanley Elkin Lola Falana Donna Fargo Bryan Forbes oligo Annette Funicello Roman Gabriel Terri Garr Judy Grahn Nicola Griffith William Hartnell Jimmy Heuga Frieda oligo Raymond Edward Johnson Inescort Barbara Jordan Jonathan Katz It Ketchum David Lander Carl Laemmle, Jr. Ronnie Lane Margaret Leighton Kathryn Lindskoog Ernie McAlister David Maclean William Newman Ken Novak Sydney Omarr Alan Osmond Richard Pryor Madlyn Rhue Keith Roberts Jordan Sigalet Kelly Sutton Aaron Solowoniuk Tamia Norah Vincent Van Vliet aka Captain Don Beefheart oligo Clay Walker Danny Wallace oligo Clifford T. Ward Paul Wellstone Angela White Montel Williams Victoria Williams
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